David M Ornitz Selected Research

Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)

1/2021	ETV4 and ETV5 drive synovial sarcoma through cell cycle and DUX4 embryonic pathway control.
1/2021	Endothelial FGF signaling is protective in hypoxia-induced pulmonary hypertension.
10/2019	FGF2-induced STAT3 activation regulates pathologic neovascularization.
10/2019	Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts.
3/2016	Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury.
1/2016	Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody.
9/2013	Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3.
1/2013	Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy.
12/2012	FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin.
3/2009	Fibroblast growth factor expression during skeletal fracture healing in mice.

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David M Ornitz Research Topics

Disease

9	Neoplasms (Cancer) 01/2021 - 03/2006
5	Adenocarcinoma of Lung 10/2019 - 09/2013
4	Lung Neoplasms (Lung Cancer) 10/2019 - 03/2015
4	Dwarfism 01/2017 - 09/2002
4	Craniosynostoses (Craniosynostosis) 07/2007 - 04/2002
3	Lung Injury 01/2020 - 01/2015
3	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2018 - 01/2015
3	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 04/2015 - 03/2007
3	Hypertrophy 01/2013 - 01/2004
2	Pulmonary Hypertension 01/2021 - 03/2019
2	Insulin Resistance 12/2020 - 04/2017
2	Fibrosis (Cirrhosis) 01/2020 - 10/2010
2	Macular Degeneration (Age-Related Maculopathy) 10/2019 - 09/2014
2	Wounds and Injuries (Trauma) 10/2019 - 12/2012
2	Carcinogenesis 10/2018 - 01/2018
2	Inflammation (Inflammations) 01/2018 - 01/2015
2	Weight Loss (Weight Reduction) 04/2017 - 01/2015
2	Achondroplasia 01/2017 - 09/2002
2	Reperfusion Injury 03/2016 - 01/2015
2	Myocardial Infarction 03/2016 - 01/2015
2	Congenital Abnormalities (Deformity) 01/2016 - 02/2010
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2016 - 09/2013
2	Synostosis 03/2009 - 07/2006
1	Virus Diseases (Viral Diseases) 01/2022
1	Infections 01/2022
1	Hypoxia (Hypoxemia) 01/2021
1	Synovial Sarcoma (Synovioma) 01/2021
1	Acanthosis Nigricans 12/2020
1	Rare Diseases (Rare Disease) 12/2020
1	Hirsutism 12/2020
1	Edema (Dropsy) 01/2020
1	Human Influenza (Influenza) 01/2020
1	Supernumerary Tooth (Supernumerary Teeth) 01/2020
1	Hyperoxia 01/2020
1	Pathologic Neovascularization 10/2019
1	Eye Diseases (Eye Disease) 10/2019
1	Choroidal Neovascularization 10/2019
1	Melanoma (Melanoma, Malignant) 10/2018
1	Lewis Lung Carcinoma 10/2018
1	Body Weight (Weight, Body) 04/2017
1	Thanatophoric Dysplasia (Dwarfism, Thanatophoric) 01/2017
1	Ciliopathies 12/2016
1	Vascular Remodeling 03/2016
1	Pleuropulmonary blastoma 05/2015
1	Ischemia 01/2015
1	Infarction (Infarctions) 01/2015
1	Heart Failure 11/2014
1	Eye Injuries (Eye Injury) 09/2014
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2013
1	Ventricular Remodeling 01/2013
1	Necrosis 10/2010

Drug/Important Bio-Agent (IBA)

17	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 01/2021 - 04/2002
14	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 01/2020 - 04/2002
5	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 10/2019 - 01/2015
5	Fibroblast Growth Factor 9IBA 01/2018 - 09/2013
4	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2006
4	Bleomycin (Blenoxane)FDA LinkGeneric 01/2020 - 01/2015
4	LigandsIBA 10/2019 - 03/2006
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2019 - 09/2014
4	Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA 02/2010 - 07/2003
3	ChemokinesIBA 01/2022 - 01/2018
3	CollagenIBA 01/2020 - 01/2017
3	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 01/2017 - 02/2004
3	fibroblast growth factor 14IBA 04/2015 - 03/2007
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 01/2020
2	CytokinesIBA 01/2022 - 01/2003
2	fibroblast growth factor 21IBA 12/2020 - 04/2017
2	Insulin (Novolin)FDA Link 12/2020 - 04/2017
2	GlycosaminoglycansIBA 01/2020 - 03/2006
2	Doxycycline (Periostat)FDA LinkGeneric 01/2018 - 01/2013
1	Interferon Type IIBA 01/2022
1	Antiviral Agents (Antivirals)IBA 01/2022
1	AZD4547IBA 01/2021
1	infigratinibIBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	isopropyl methylphosphonic acidIBA 12/2020
1	indium-bleomycinIBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2020
1	Xylose (D-Xylose)FDA Link 01/2020
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 10/2018
1	Neutralizing AntibodiesIBA 10/2018
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 10/2018
1	Matrix Metalloproteinases (MMPs)IBA 01/2018
1	AdiponectinIBA 04/2017
1	Hormones (Hormone)IBA 04/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2016
1	Monoclonal AntibodiesIBA 01/2016
1	Indicators and Reagents (Reagents)IBA 01/2016
1	MicroRNAs (MicroRNA)IBA 05/2015
1	Evans Blue (Blue, Evans)FDA Link 01/2015
1	Coloring Agents (Dyes)IBA 01/2015
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2015
1	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 09/2014
1	Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA 01/2013
1	Type 4 Fibroblast Growth Factor ReceptorIBA 10/2010
1	Bile Acids and Salts (Bile Acids)IBA 10/2010

Therapy/Procedure

6	Therapeutics 10/2019 - 09/2008
2	Sutures (Suture) 03/2009 - 07/2006
1	Drug Therapy (Chemotherapy) 03/2019
1	Transplantation 10/2018